Conditions
Condition-specific guides on CBD for autoimmune and inflammatory conditions. We follow the evidence wherever it leads — including when it leads to "not enough data to draw conclusions."
Each guide maps the ECS mechanism, cites the available human and animal research, and is honest about evidence gaps. Drug interactions for any medications you're already taking are covered in the drug interactions hub.
Rheumatoid arthritis
ICD-10 M05
The mechanism map, honest evidence picture, and drug-interaction realities for RA and chronic inflammatory joint pain. Written by Ron, living with RA for 30+ years.
Hashimoto's thyroiditis
ICD-10 E06.3
Educational framing only, no clinical trials for Hashimoto's + CBD. How the immune system connects to thyroid autoimmunity, a thyroid safety signal worth knowing about, levothyroxine timing, and what patients actually use CBD for.
Lupus (SLE)
ICD-10 M32
No clinical trials for SLE + CBD, and no published data on why lupus patients use it. Medication table covers plaquenil, prednisone, mycophenolate, belimumab, and azathioprine.
Knee osteoarthritis
ICD-10 M17
Why the knee suits a topical, when oral makes sense, and what the joint research shows. NSAIDs, celecoxib, meloxicam, and duloxetine interaction table.
Fibromyalgia
ICD-10 M79.7
Boehnke 2021 (n=2,701 survey): fibromyalgia patients using CBD generally reported slight to much improvement across their symptoms, most commonly pain. No CBD-specific RCT, cannabis (THC+CBD) trials show stronger signal. Why fibro's pain-amplification biology makes CBD worth exploring. Medication table: duloxetine, pregabalin, SSRIs, tricyclics, tramadol.
Psoriatic arthritis
ICD-10 L40.5
Joints vs skin: why PsA's two components are separate questions for oral and topical CBD. The ECS-immune mechanism (CB2 receptors, Th1/Th17 modulation) explained as mechanism, not proof. Medication table: methotrexate, biologics, JAK inhibitors, NSAIDs, prednisone.
Ankylosing spondylitis
ICD-10 M45
No AS-specific CBD trial or human data exists. The immune biology behind AS and where CBD might fit in; why topical CBD won't reach your spine or sacroiliac joints. Medication table: NSAIDs, biologics (TNF + IL-17), JAK inhibitors, sulfasalazine.
Hip osteoarthritis
ICD-10 M16
No hip-specific trial yet; the joint research comes from animal studies. Key distinction: hip is a deep joint; topical CBD cannot reach it. Oral CBD is the route. Medication table: acetaminophen, NSAIDs, celecoxib, meloxicam, duloxetine, tramadol.
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Gout, ankylosing spondylitis peripheral subtype, and sleep-specific conditions are in the research queue. Each takes time to do properly — we won't publish without primary citations.